cyclin-dependent kinase inhibitor 1C (p57, Kip2)


CDKN1C (may also be known as: None)




This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]


Cdkn1c Mus musculus
Cdkn1c Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000080 G1 phase of mitotic cell cycle biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0007049 cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0033673 negative regulation of kinase activity biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0042551 neuron maturation biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0050680 negative regulation of epithelial cell proliferation biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004860 protein kinase inhibitor activity molecular_function
GO:0004861 cyclin-dependent protein kinase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function