cytokine inducible SH2-containing protein


CISH (may also be known as: None)




The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]


socs8 Danio rerio
Cish Mus musculus
Cish Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001558 regulation of cell growth biological_process
GO:0009968 negative regulation of signal transduction biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway biological_process
GO:0005575 cellular_component cellular_component
GO:0005622 intracellular cellular_component
GO:0005829 cytosol cellular_component
GO:0003674 molecular_function molecular_function