complement factor D (adipsin)


CFD (may also be known as: None)




The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]


cfd Danio rerio
Cfd Mus musculus
Cfd Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2392 complement factor D preproprotein decreases with age Molecular dermis Human CFD 21.7% Decrease DNA Methylation
DAA2441 complement factor D preproprotein increases with age Molecular mesenchymal stem cell Human CFD 22.2% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0002576 platelet degranulation biological_process
GO:0006508 proteolysis biological_process
GO:0006956 complement activation biological_process
GO:0006957 complement activation, alternative pathway biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007596 blood coagulation biological_process
GO:0030168 platelet activation biological_process
GO:0045087 innate immune response biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0031093 platelet alpha granule lumen cellular_component
GO:0004252 serine-type endopeptidase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008236 serine-type peptidase activity molecular_function