engrailed homeobox 1


EN1 (may also be known as: None)




Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]


eng1b Danio rerio
En1 Mus musculus
En1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2415 engrailed homolog 1 increases with age Molecular dermis Human EN1 18.8% Increase DNA Methylation

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1756 engrailed 1 Molecular muscle Mouse En1 8.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0007275 multicellular organismal development biological_process
GO:0009653 anatomical structure morphogenesis biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0009954 proximal/distal pattern formation biological_process
GO:0030901 midbrain development biological_process
GO:0030902 hindbrain development biological_process
GO:0030917 midbrain-hindbrain boundary development biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0043473 pigmentation biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048666 neuron development biological_process
GO:0005634 nucleus cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function