E1A binding protein p300


EP300 (may also be known as: None)




This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]


ep300a Danio rerio
Ep300 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2066 E1A binding protein p300 decreases with age Molecular ovary Human EP300 69.2% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001666 response to hypoxia biological_process
GO:0001756 somitogenesis biological_process
GO:0001889 liver development biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006915 apoptotic process biological_process
GO:0007049 cell cycle biological_process
GO:0007399 nervous system development biological_process
GO:0007507 heart development biological_process
GO:0007519 skeletal muscle tissue development biological_process
GO:0009749 response to glucose stimulus biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010560 positive regulation of glycoprotein biosynthetic process biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0016573 histone acetylation biological_process
GO:0018076 N-terminal peptidyl-lysine acetylation biological_process
GO:0018393 internal peptidyl-lysine acetylation biological_process
GO:0030324 lung development biological_process
GO:0031324 negative regulation of cellular metabolic process biological_process
GO:0031325 positive regulation of cellular metabolic process biological_process
GO:0032025 response to cobalt ion biological_process
GO:0032092 positive regulation of protein binding biological_process
GO:0032526 response to retinoic acid biological_process
GO:0032967 positive regulation of collagen biosynthetic process biological_process
GO:0033160 positive regulation of protein import into nucleus, translocation biological_process
GO:0042493 response to drug biological_process
GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process
GO:0043388 positive regulation of DNA binding biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043627 response to estrogen stimulus biological_process
GO:0043923 positive regulation by host of viral transcription biological_process
GO:0043967 histone H4 acetylation biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045087 innate immune response biological_process
GO:0045471 response to ethanol biological_process
GO:0045727 positive regulation of translation biological_process
GO:0045773 positive regulation of axon extension biological_process
GO:0045793 positive regulation of cell size biological_process
GO:0045862 positive regulation of proteolysis biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048565 digestive tract development biological_process
GO:0050714 positive regulation of protein secretion biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051592 response to calcium ion biological_process
GO:0060177 regulation of angiotensin metabolic process biological_process
GO:0060298 positive regulation of sarcomere organization biological_process
GO:0060765 regulation of androgen receptor signaling pathway biological_process
GO:0065004 protein-DNA complex assembly biological_process
GO:0070301 cellular response to hydrogen peroxide biological_process
GO:0070542 response to fatty acid biological_process
GO:0000123 histone acetyltransferase complex cellular_component
GO:0000785 chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0032993 protein-DNA complex cellular_component
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding molecular_function
GO:0001047 core promoter binding molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0003823 antigen binding molecular_function
GO:0004402 histone acetyltransferase activity molecular_function
GO:0004468 lysine N-acetyltransferase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016407 acetyltransferase activity molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0032403 protein complex binding molecular_function
GO:0033613 activating transcription factor binding molecular_function
GO:0035259 glucocorticoid receptor binding molecular_function
GO:0042975 peroxisome proliferator activated receptor binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050681 androgen receptor binding molecular_function
GO:0051019 mitogen-activated protein kinase binding molecular_function
GO:0051059 NF-kappaB binding molecular_function