erythrocyte membrane protein band 4.2


EPB42 (may also be known as: None)




Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


Epb42 Mus musculus
Epb42 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0008360 regulation of cell shape biological_process
GO:0018149 peptide cross-linking biological_process
GO:0043249 erythrocyte maturation biological_process
GO:0005737 cytoplasm cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005886 plasma membrane cellular_component
GO:0003810 protein-glutamine gamma-glutamyltransferase activity molecular_function
GO:0005200 structural constituent of cytoskeleton molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function