adenine phosphoribosyltransferase


APRT (may also be known as: None)




Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


T19B4.3 Caenorhabditis elegans
Aprt Drosophila melanogaster
aprt Danio rerio
Aprt Mus musculus
Aprt Rattus norvegicus
APT2 Saccharomyces cerevisiae
apt1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006144 purine base metabolic process biological_process
GO:0006166 purine ribonucleoside salvage biological_process
GO:0006168 adenine salvage biological_process
GO:0007595 lactation biological_process
GO:0007625 grooming behavior biological_process
GO:0009116 nucleoside metabolic process biological_process
GO:0043101 purine-containing compound salvage biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055086 nucleobase-containing small molecule metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0002055 adenine binding molecular_function
GO:0003999 adenine phosphoribosyltransferase activity molecular_function
GO:0016208 AMP binding molecular_function
GO:0016757 transferase activity, transferring glycosyl groups molecular_function