keratin 6A


KRT6A (may also be known as: None)




The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3225 Gene expression of KRT6A decreases with age Molecular skin Human KRT6A
DAA2422 keratin 6A decreases with age Molecular dermis Human KRT6A 16.7% Decrease DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0007398 ectoderm development biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0030154 cell differentiation biological_process
GO:0005882 intermediate filament cellular_component
GO:0045095 keratin filament cellular_component
GO:0005198 structural molecule activity molecular_function
GO:0005200 structural constituent of cytoskeleton molecular_function
GO:0005515 protein binding molecular_function