lecithin-cholesterol acyltransferase


LCAT (may also be known as: None)




This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]


CELE_M05B5.4 Caenorhabditis elegans
CG18858 Drosophila melanogaster
lcat Danio rerio
Lcat Mus musculus
Lcat Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006629 lipid metabolic process biological_process
GO:0006644 phospholipid metabolic process biological_process
GO:0006656 phosphatidylcholine biosynthetic process biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0030301 cholesterol transport biological_process
GO:0034372 very-low-density lipoprotein particle remodeling biological_process
GO:0034375 high-density lipoprotein particle remodeling biological_process
GO:0034435 cholesterol esterification biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042158 lipoprotein biosynthetic process biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0046688 response to copper ion biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0090107 regulation of high-density lipoprotein particle assembly biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0034364 high-density lipoprotein particle cellular_component
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity molecular_function
GO:0004623 phospholipase A2 activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function
GO:0034186 apolipoprotein A-I binding molecular_function