solute carrier family 22, member 18


SLC22A18 (may also be known as: None)




This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]


C53B4.3 Caenorhabditis elegans
slc22a18 Danio rerio
Slc22a18 Mus musculus
Slc22a18 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006811 ion transport biological_process
GO:0006855 drug transmembrane transport biological_process
GO:0007588 excretion biological_process
GO:0015695 organic cation transport biological_process
GO:0015893 drug transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005635 nuclear envelope cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0044444 cytoplasmic part cellular_component
GO:0005215 transporter activity molecular_function
GO:0015238 drug transmembrane transporter activity molecular_function
GO:0015293 symporter activity molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function