angiotensin I converting enzyme 2


ACE2 (may also be known as: None)




The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]


acn-1 Caenorhabditis elegans
Ance-3 Drosophila melanogaster
ace2 Danio rerio
Ace2 Mus musculus
Ace2 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001817 regulation of cytokine production biological_process
GO:0002005 angiotensin catabolic process in blood biological_process
GO:0003051 angiotensin-mediated drinking behavior biological_process
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin biological_process
GO:0006508 proteolysis biological_process
GO:0009615 response to virus biological_process
GO:0019229 regulation of vasoconstriction biological_process
GO:0032800 receptor biosynthetic process biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0042312 regulation of vasodilation biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0046718 entry of virus into host cell biological_process
GO:0046813 virion attachment, binding of host cell surface receptor biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:2000379 positive regulation of reactive oxygen species metabolic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0001618 viral receptor activity molecular_function
GO:0001948 glycoprotein binding molecular_function
GO:0004175 endopeptidase activity molecular_function
GO:0004180 carboxypeptidase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008237 metallopeptidase activity molecular_function
GO:0008241 peptidyl-dipeptidase activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0046872 metal ion binding molecular_function