B-cell CLL/lymphoma 6


BCL6 (may also be known as: None)




The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]


bcl6a Danio rerio
Bcl6 Mus musculus
Bcl6 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000902 cell morphogenesis biological_process
GO:0001953 negative regulation of cell-matrix adhesion biological_process
GO:0002467 germinal center formation biological_process
GO:0002634 regulation of germinal center formation biological_process
GO:0002829 negative regulation of type 2 immune response biological_process
GO:0002903 negative regulation of B cell apoptosis biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0007283 spermatogenesis biological_process
GO:0008104 protein localization biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030183 B cell differentiation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0032319 regulation of Rho GTPase activity biological_process
GO:0032764 negative regulation of mast cell cytokine production biological_process
GO:0035024 negative regulation of Rho protein signal transduction biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043380 regulation of memory T cell differentiation biological_process
GO:0045596 negative regulation of cell differentiation biological_process
GO:0045629 negative regulation of T-helper 2 cell differentiation biological_process
GO:0045749 negative regulation of S phase of mitotic cell cycle biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0048294 negative regulation of isotype switching to IgE isotypes biological_process
GO:0048821 erythrocyte development biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050776 regulation of immune response biological_process
GO:0051272 positive regulation of cellular component movement biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005657 replication fork cellular_component
GO:0005730 nucleolus cellular_component
GO:0003676 nucleic acid binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function