B-cell CLL/lymphoma 6
Symbol
BCL6
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Orthologs
Symbol | Species | |
---|---|---|
bcl6a | Danio rerio | |
Bcl6 | Mus musculus | |
Bcl6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA3009 | Gene expression of BCL6 increases with age | Molecular | skin | Human | BCL6 | — | |
DAA2783 | Gene expression of BCL6 decreases with age | Molecular | adipose tissue | Human | BCL6 | — |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000060 | protein import into nucleus, translocation | biological_process | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
GO:0000902 | cell morphogenesis | biological_process | |
GO:0001953 | negative regulation of cell-matrix adhesion | biological_process | |
GO:0002467 | germinal center formation | biological_process | |
GO:0002634 | regulation of germinal center formation | biological_process | |
GO:0002829 | negative regulation of type 2 immune response | biological_process | |
GO:0002903 | negative regulation of B cell apoptosis | biological_process | |
GO:0006974 | response to DNA damage stimulus | biological_process | |
GO:0007283 | spermatogenesis | biological_process | |
GO:0008104 | protein localization | biological_process | |
GO:0008285 | negative regulation of cell proliferation | biological_process | |
GO:0030036 | actin cytoskeleton organization | biological_process | |
GO:0030183 | B cell differentiation | biological_process | |
GO:0030308 | negative regulation of cell growth | biological_process | |
GO:0030890 | positive regulation of B cell proliferation | biological_process | |
GO:0032319 | regulation of Rho GTPase activity | biological_process | |
GO:0032764 | negative regulation of mast cell cytokine production | biological_process | |
GO:0035024 | negative regulation of Rho protein signal transduction | biological_process | |
GO:0043065 | positive regulation of apoptotic process | biological_process | |
GO:0043066 | negative regulation of apoptotic process | biological_process | |
GO:0043380 | regulation of memory T cell differentiation | biological_process | |
GO:0045596 | negative regulation of cell differentiation | biological_process | |
GO:0045629 | negative regulation of T-helper 2 cell differentiation | biological_process | |
GO:0045749 | negative regulation of S phase of mitotic cell cycle | biological_process | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological_process | |
GO:0048294 | negative regulation of isotype switching to IgE isotypes | biological_process | |
GO:0048821 | erythrocyte development | biological_process | |
GO:0050727 | regulation of inflammatory response | biological_process | |
GO:0050776 | regulation of immune response | biological_process | |
GO:0051272 | positive regulation of cellular component movement | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005634 | nucleus | cellular_component | |
GO:0005657 | replication fork | cellular_component | |
GO:0005730 | nucleolus | cellular_component | |
GO:0003676 | nucleic acid binding | molecular_function | |
GO:0003682 | chromatin binding | molecular_function | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0008270 | zinc ion binding | molecular_function | |
GO:0031490 | chromatin DNA binding | molecular_function | |
GO:0043565 | sequence-specific DNA binding | molecular_function | |
GO:0046872 | metal ion binding | molecular_function | |