PDZ and LIM domain 2 (mystique)


PDLIM2 (may also be known as: None)




This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]


pdlim2 Danio rerio
Pdlim2 Mus musculus
Pdlim2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2407 PDZ and LIM domain 2 isoform 3 decreases with age Molecular dermis Human PDLIM2 17.3% Decrease DNA Methylation
DAA2456 PDZ and LIM domain 2 isoform 3 increases with age Molecular mesenchymal stem cell Human PDLIM2 43.9% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0001725 stress fiber cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005925 focal adhesion cellular_component
GO:0009986 cell surface cellular_component
GO:0015629 actin cytoskeleton cellular_component
GO:0030864 cortical actin cytoskeleton cellular_component
GO:0008270 zinc ion binding molecular_function
GO:0031006 filamin-A binding molecular_function
GO:0032036 myosin heavy chain binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0051371 muscle alpha-actinin binding molecular_function
GO:0051372 nonmuscle alpha-actinin binding molecular_function