bone morphogenetic protein 6


BMP6 (may also be known as: None)




The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]


Bmp6 Mus musculus
Bmp6 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0001654 eye development biological_process
GO:0001822 kidney development biological_process
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0001958 endochondral ossification biological_process
GO:0006954 inflammatory response biological_process
GO:0006955 immune response biological_process
GO:0007275 multicellular organismal development biological_process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation biological_process
GO:0030501 positive regulation of bone mineralization biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0030539 male genitalia development biological_process
GO:0032349 positive regulation of aldosterone biosynthetic process biological_process
GO:0040007 growth biological_process
GO:0045603 positive regulation of endothelial cell differentiation biological_process
GO:0045666 positive regulation of neuron differentiation biological_process
GO:0045669 positive regulation of osteoblast differentiation biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0051216 cartilage development biological_process
GO:0060395 SMAD protein signal transduction biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005125 cytokine activity molecular_function
GO:0008083 growth factor activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0070700 BMP receptor binding molecular_function