BMX non-receptor tyrosine kinase


BMX (may also be known as: None)




This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]


Bmx Mus musculus
Bmx Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006468 protein phosphorylation biological_process
GO:0006915 apoptotic process biological_process
GO:0006921 cellular component disassembly involved in apoptosis biological_process
GO:0006950 response to stress biological_process
GO:0007155 cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007498 mesoderm development biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0032587 ruffle membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function