tumor necrosis factor






Tnf Mus musculus
Tnf Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000165 MAPKKK cascade biological_process
GO:0000185 activation of MAPKKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0001666 response to hypoxia biological_process
GO:0001775 cell activation biological_process
GO:0001819 positive regulation of cytokine production biological_process
GO:0001932 regulation of protein phosphorylation biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002037 negative regulation of L-glutamate transport biological_process
GO:0002439 chronic inflammatory response to antigenic stimulus biological_process
GO:0002740 negative regulation of cytokine secretion involved in immune response biological_process
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus biological_process
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin biological_process
GO:0003009 skeletal muscle contraction biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006927 transformed cell apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0006959 humoral immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0008625 induction of apoptosis via death domain receptors biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009615 response to virus biological_process
GO:0009651 response to salt stress biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0010888 negative regulation of lipid storage biological_process
GO:0010940 positive regulation of necrotic cell death biological_process
GO:0014823 response to activity biological_process
GO:0019722 calcium-mediated signaling biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0030730 sequestering of triglyceride biological_process
GO:0031334 positive regulation of protein complex assembly biological_process
GO:0031622 positive regulation of fever generation biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032715 negative regulation of interleukin-6 production biological_process
GO:0032722 positive regulation of chemokine production biological_process
GO:0032729 positive regulation of interferon-gamma production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032800 receptor biosynthetic process biological_process
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0033209 tumor necrosis factor-mediated signaling pathway biological_process
GO:0034116 positive regulation of heterotypic cell-cell adhesion biological_process
GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process
GO:0042493 response to drug biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043068 positive regulation of programmed cell death biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043243 positive regulation of protein complex disassembly biological_process
GO:0043406 positive regulation of MAP kinase activity biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043525 positive regulation of neuron apoptosis biological_process
GO:0044130 negative regulation of growth of symbiont in host biological_process
GO:0045071 negative regulation of viral genome replication biological_process
GO:0045080 positive regulation of chemokine biosynthetic process biological_process
GO:0045123 cellular extravasation biological_process
GO:0045416 positive regulation of interleukin-8 biosynthetic process biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0045670 regulation of osteoclast differentiation biological_process
GO:0045672 positive regulation of osteoclast differentiation biological_process
GO:0045840 positive regulation of mitosis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0045994 positive regulation of translational initiation by iron biological_process
GO:0046325 negative regulation of glucose import biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0048566 embryonic digestive tract development biological_process
GO:0048661 positive regulation of smooth muscle cell proliferation biological_process
GO:0050715 positive regulation of cytokine secretion biological_process
GO:0050796 regulation of insulin secretion biological_process
GO:0050806 positive regulation of synaptic transmission biological_process
GO:0050830 defense response to Gram-positive bacterium biological_process
GO:0050901 leukocyte tethering or rolling biological_process
GO:0050995 negative regulation of lipid catabolic process biological_process
GO:0051023 regulation of immunoglobulin secretion biological_process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051222 positive regulation of protein transport biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051533 positive regulation of NFAT protein import into nucleus biological_process
GO:0051798 positive regulation of hair follicle development biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0060555 induction of necroptosis by extracellular signals biological_process
GO:0060557 positive regulation of vitamin D biosynthetic process biological_process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity biological_process
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis biological_process
GO:0060693 regulation of branching involved in salivary gland morphogenesis biological_process
GO:0061048 negative regulation of branching involved in lung morphogenesis biological_process
GO:0070265 necrotic cell death biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0071230 cellular response to amino acid stimulus biological_process
GO:0071316 cellular response to nicotine biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:0071803 positive regulation of podosome assembly biological_process
GO:0097191 extrinsic apoptotic signaling pathway biological_process
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production biological_process
GO:0001891 phagocytic cup cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005622 intracellular cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0055037 recycling endosome cellular_component
GO:0002020 protease binding molecular_function
GO:0005125 cytokine activity molecular_function
GO:0005164 tumor necrosis factor receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function