syncoilin, intermediate filament protein


SYNC (may also be known as: None)




This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]


sync Danio rerio
Sync Mus musculus
Sync Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2389 syncoilin; intermediate filament 1 decreases with age Molecular dermis Human SYNC 16.0% Decrease DNA Methylation
DAA2438 syncoilin; intermediate filament 1 increases with age Molecular mesenchymal stem cell Human SYNC 21.4% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0045103 intermediate filament-based process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005882 intermediate filament cellular_component
GO:0030018 Z disc cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0042383 sarcolemma cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005198 structural molecule activity molecular_function