cyclin-dependent kinase 5, regulatory subunit 1 (p35)


CDK5R1 (may also be known as: None)




The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]


Cdk5alpha Drosophila melanogaster
cdk5r1b Danio rerio
Cdk5r1 Mus musculus
Cdk5r1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0001764 neuron migration biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007158 neuron cell-cell adhesion biological_process
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway biological_process
GO:0007411 axon guidance biological_process
GO:0007413 axonal fasciculation biological_process
GO:0007420 brain development biological_process
GO:0008283 cell proliferation biological_process
GO:0009790 embryo development biological_process
GO:0016310 phosphorylation biological_process
GO:0018105 peptidyl-serine phosphorylation biological_process
GO:0018107 peptidyl-threonine phosphorylation biological_process
GO:0021799 cerebral cortex radially oriented cell migration biological_process
GO:0030182 neuron differentiation biological_process
GO:0031175 neuron projection development biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0035235 ionotropic glutamate receptor signaling pathway biological_process
GO:0043525 positive regulation of neuron apoptosis biological_process
GO:0045664 regulation of neuron differentiation biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0048013 ephrin receptor signaling pathway biological_process
GO:0061001 regulation of dendritic spine morphogenesis biological_process
GO:0070507 regulation of microtubule cytoskeleton organization biological_process
GO:0071902 positive regulation of protein serine/threonine kinase activity biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0014069 postsynaptic density cellular_component
GO:0016020 membrane cellular_component
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex cellular_component
GO:0030424 axon cellular_component
GO:0030425 dendrite cellular_component
GO:0030426 growth cone cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043197 dendritic spine cellular_component
GO:0043292 contractile fiber cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004672 protein kinase activity molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0016534 cyclin-dependent protein kinase 5 activator activity molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0043539 protein serine/threonine kinase activator activity molecular_function
GO:0045296 cadherin binding molecular_function