activin A receptor, type IB

Symbol

ACVR1B (may also be known as: None)

Organism

Human

Description

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Orthologs

SymbolSpecies
LOC559222 Danio rerio
Acvr1b Mus musculus
Acvr1b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2977 Gene expression of ACVR1B increases with age Molecular skin Human ACVR1B —
DAA2062 activin A receptor, type IB increases with age Molecular ovary Human ACVR1B 51.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001942 hair follicle development biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006917 induction of apoptosis biological_process
GO:0007165 signal transduction biological_process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0007417 central nervous system development biological_process
GO:0009790 embryo development biological_process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation biological_process
GO:0018107 peptidyl-threonine phosphorylation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0032924 activin receptor signaling pathway biological_process
GO:0032927 positive regulation of activin receptor signaling pathway biological_process
GO:0045648 positive regulation of erythrocyte differentiation biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046545 development of primary female sexual characteristics biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0048179 activin receptor complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004675 transmembrane receptor protein serine/threonine kinase activity molecular_function
GO:0004702 receptor signaling protein serine/threonine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005024 transforming growth factor beta-activated receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016361 activin receptor activity, type I molecular_function
GO:0017002 activin-activated receptor activity molecular_function
GO:0019838 growth factor binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0034711 inhibin binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0048185 activin binding molecular_function