Weiskopf et al. (2009) "The aging of the immune system." Transpl. Int. 22(11):1041-1050 (PubMed) (28 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA940 B naive cells' susceptibility to apoptosis decreases Physiological memory B cell Human
DAA972 Chemotaxis and adhesion activity unchanged in vitro Physiological neutrophil Human
DAA968 Chronic inflammation increases Physiological blood, immune system Human
DAA949 Cytomegalovirus infection incidence increases Pathological immune system Human
DAA986 Cytotoxicity and interleukin-2 response of natural killer cells decreases Physiological natural killer cell Human
DAA1229 Declining T-lymphocyte production in the thymus Physiological thymus Human
DAA991 Decreased function of epithelial barriers Physiological lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis Human
DAA983 Diminished superoxide production in response to Fc Physiological neutrophil Human
DAA963 Expansion into effector cells is reduced Physiological naïve T cell Human
DAA985 Functional decline and decreases in macrophage numbers in bone marrow Physiological macrophage Human
DAA988 Function declines Physiological dendritic cell Mouse
DAA950 Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals Physiological immune system Human
DAA987 Increase in total number of cells Physiological natural killer cell Human
DAA962 Interleukin-2 production in response to influenza vaccine declines Physiological T cell Human IL2
DAA943 Lower affinity antibodies generated Physiological B cell Mouse
DAA939 Naive cell number increases and memory cells decrease Physiological B cell Human
DAA933 No changes in erythroid and myeloid progenitor cells evident Physiological myeloid progenitor cell Human
DAA934 Number of mature B cells leaving the bone marrow declines Physiological bone marrow, B cell Human
DAA980 Phagocytosis activity decreased in response to opsonized targets Physiological neutrophil Human
DAA981 Phagocytosis activity unchanged in response to unopsonized targets Physiological neutrophil Human
DAA935 Pro-B cell generation and differentiation declines Physiological bone marrow, B cell Human
DAA960 Receptor expression alterations Physiological grey matter Human
DAA932 Renewal capacity declines Physiological hematopoietic stem cells Human
DAA964 T-cell diversity declines Physiological T cell Human
DAA959 telomere shortening Molecular naïve T cell Human