Sharma et al. (2009) "The aging immune system and its relationship to the development of chronic obstructive pulmonary disease." Proc Am Thorac Soc 6(7):573-580 (PubMed) (13 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA821 Chronic obstructive pulmonary disease incidence increases Pathological lung Human
DAA822 Small airway obstruction Pathological lung Human
DAA953 Increase in cells that are both CD8+ and CD28-null Physiological T regulatory cell Human
DAA975 Infiltration at injury site is reduced Physiological neutrophil Human
DAA955 Interleukin-7 production declines Physiological stromal cell Human IL7
DAA944 Less antibodies generated Physiological B cell Human
DAA954 Number of T cell progenitors declines Physiological T cell progenitor Human
DAA956 Proliferation is reduced Physiological lymphocytes Human
DAA960 Receptor expression alterations Physiological grey matter Human
DAA964 T-cell diversity declines Physiological T cell Human
DAA974 Chemotaxis is reduced Physiological neutrophil, dendritic cell Human
DAA936 Volume of hematopoietic bone marrow decreases Physiological bone marrow Human
DAA952 Fewer CD4+ and CD8+ cells Physiological T cell Human